Carnal Art, a form of sculpture initiated by the French artist Orlan, uses the human body as a basic material and plastic surgery as a method of creation. Orlan has stated: “My work is a struggle against the innate, the inexorable, the programmed, Nature, DNA (which is our direct rival as far as artists of representation are concerned), and God!”
Transhumanism, abbreviated as H+, is an international intellectual and cultural movement that affirms the possibility and desirability of fundamentally transforming the human condition to eliminate aging and to greatly enhance human intellectual, physical, and psychological capacities. They predict that human beings may eventually be able to transform themselves into beings with such greatly expanded abilities as to merit the label of "posthuman".
Natasha Vita-More, chair of H+, her research concerns the aesthetics of human enhancement and radical life expansion, with a focus on sciences and technologies. Since the 1990s, she has focused on the relationship between design, science and technology. Her work approaches human enhancement and methods for elevating human capabilities toward life expansion.
The transhumanist thinkers rely on biotechnology and other emerging technologies. For some artists as transhumanists and bio-art, they are looking for new media of expression, for others they want to achieve immortality (immortalist movement) through technology extension and biomedicalization.
Other artists explore themes related to the transformation of the body, such as the performance artist Marina Abramovic. In 2005, an exhibition called "Becoming Animal" at the Museum of Contemporary Art in Massachusetts presented works of twelve artists whose works deal with the effects of technology to erase the boundary between humans and non-humans.